HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid → 4-(4-chlorophenyl)-N-(4-methoxy-3-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-pyrrole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid | HCID 12897099 | — |
| Reactant | 4-methoxy-3-[2-(1-pyrrolidinyl)ethoxy]Benzenamine | HCID 18980128 | — |
| Product | 4-(4-chlorophenyl)-N-(4-methoxy-3-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-pyrrole-2-carboxamide | HCID 67214647 | 74% |
Reaction Steps
Acylation of 4-methoxy-3-(2-(pyrrolidin-1-yl)ethoxy)benzenamine from step A with 4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid to generate the title compound in 74% yield was achieved via the procedure described in step C of Example 1. MS (ESI) 440 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07956049B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-35d1fae9738f4757a90a16a2e470dc67 |
| Source note | uspto-grants-2011_06 |