4-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid → HCID 67215141, compound

HRID 2420715Notes

Reaction equation

HRID 2420715 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:14])[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[N:12][CH:11]=[N:10]1.[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:23]=[C:24]([C:27](O)=[O:28])[NH:25][CH:26]=2)=[CH:18][CH:17]=1>>[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:23]=[C:24]([C:27]([NH:14][C:5]3[CH:6]=[CH:7][C:8]([N:9]4[CH:13]=[N:12][CH:11]=[N:10]4)=[C:3]([O:2][CH3:1])[CH:4]=3)=[O:28])[NH:25][CH:26]=2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 128970994-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acidHCID 22459694HCID 22459694, compound

Product 1

HCID 67215141HCID 67215141, compound

Procedure

3-Methoxy-4-(1H-1,2,4-triazol-1-yl)benzenamine, prepared as described in Bioorg. Med. Chem. Lett, 13:2059 (2003), was converted to the title compound (45 mg) by acylation with 4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid (30 mg) following the procedure described in step C of Example 1. MS (ESI) 394 (M+H)+.

Sources & evidence

ORD record
ord-890eb653ea8746c696ae03b42461d715
Source dataset
uspto-grants-2011_06
Patent number
US07956049B2

Reaction notes

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