HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid → 4-(4-chlorophenyl)-N-(3-methoxy-4-(2-(tetrahydrofuran-2-yl)ethoxy)phenyl)-1H-pyrrole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid | HCID 12897099 | — |
| Reactant | 3-Methoxy-4-(2-(tetrahydrofuran-2-yl)ethoxy)aniline | HCID 65158956 | — |
| Product | 4-(4-chlorophenyl)-N-(3-methoxy-4-(2-(tetrahydrofuran-2-yl)ethoxy)phenyl)-1H-pyrrole-2-carboxamide | HCID 67215186 | 98% |
Reaction Steps
Acylation of 3-methoxy-4-(2-(tetrahydrofuran-2-yl)ethoxy)aniline from step A with 4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid to generate the title compound in 98% yield was achieved via the procedure described in step C of Example 1. The crude product was used for next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07956049B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-3146f8af39ab4069a516445f43acef1f |
| Source note | uspto-grants-2011_06 |