2,4-Dichlorobenzylidenemalononitrile → HCID 67214683, compound

HRID 2420790Notes

Reaction equation

HRID 2420790 reaction equation
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([NH2:10])=[N:2]1.[Cl:11][C:12]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:13]=1[CH:14]=[C:15]([C:18]#[N:19])[C:16]#[N:17]>>[NH2:19][C:18]1[N:2]2[N:1]=[C:5]3[N:6]=[CH:7][CH:8]=[CH:9][C:4]3=[C:3]2[N:10]=[C:14]([C:13]2[CH:20]=[CH:21][C:22]([Cl:24])=[CH:23][C:12]=2[Cl:11])[C:15]=1[C:16]#[N:17]

Participants

3

Reactant 2

HCID 180892,4-Dichlorobenzylidenemalononitrile2×HCID 178509226HCID 178509226, compound

Product 1

HCID 67214683HCID 67214683, compound

Procedure

Commercial 1H-pyrazolo[3,4-b]pyridin-3-amine and (2,4-dichlorobenzylidene)malononitrile (Intermediate 1) were reacted according to the procedure of Example 1, Step A, and the crude product was purified by preparative HPLC (C18 reverse phase column, gradient elution with 10-80% acetonitrile in water containing 0.05% trifluoroacetic acid) to give the title compound as a yellow solid. LC-MS 355 (M+1).

Workup

  1. customthe crude product was purified by preparative HPLC (
  2. washC18 reverse phase column, gradient elution with 10-80% acetonitrile in water containing 0.05% trifluoroacetic acid)

Sources & evidence

ORD record
ord-eb468269e451452a91b6cd3817ce64cf
Source dataset
uspto-grants-2011_06
Patent number
US07956061B2

Reaction notes

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