2,4-Dichlorobenzylidenemalononitrile → HCID 67214799, compound

HRID 2420791Notes

Reaction equation

HRID 2420791 reaction equation
[NH2:1][C:2]1[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][NH:4][N:3]=1.[Cl:12][C:13]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:14]=1[CH:15]=[C:16]([C:19]#[N:20])[C:17]#[N:18]>>[NH2:20][C:19]1[N:3]2[N:4]=[CH:5][C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[C:2]2[N:1]=[C:15]([C:14]2[CH:21]=[CH:22][C:23]([Cl:25])=[CH:24][C:13]=2[Cl:12])[C:16]=1[C:17]#[N:18]

Participants

3

Reactant 2

HCID 180892,4-Dichlorobenzylidenemalononitrile2×HCID 178469928HCID 178469928, compound

Product 1

HCID 67214799HCID 67214799, compound

Procedure

Commercial 3-amino-4-carbethoxypyrazole and (2,4-dichlorobenzylidene)malononitrile (Intermediate 1) were reacted according to the procedure of Example 1, Step A, and the crude product was purified by preparative HPLC(C18 reverse phase column, gradient elution with 30-80% acetonitrile in water containing 0.05% trifluoroacetic acid) to give the title compound as a reddish-orange solid. LC-MS 376 (M+1).

Workup

  1. customthe crude product was purified by preparative HPLC(C18
  2. washreverse phase column, gradient elution with 30-80% acetonitrile in water containing 0.05% trifluoroacetic acid)

Sources & evidence

ORD record
ord-4791c0d823a6450a9e4c2203e25eb943
Source dataset
uspto-grants-2011_06
Patent number
US07956061B2

Reaction notes

Loading…