HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2420889Generated: November 1, 2026
Thionyl Chloride → 1-(4-Methoxyphenyl)cyclopropane-1-carbonyl chloride
https://huagongshe.com/reaction/2420889
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-(4-Methoxyphenyl)cyclopropane-1-carboxylic acid | HCID 85575 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(4-Methoxyphenyl)cyclopropane-1-carbonyl chloride | HCID 24273707 | — |
Reaction Steps
To 1-(4-methoxyphenyl)cyclopropanecarboxylic acid (4.07 g, 21.2 mmol) were added thionyl chloride (4.64 mL, 63.5 mmol) and DMF (64 μL). The mixture was heated at 50° C. for 45 minutes. The excess thionyl chloride was evaporated under reduced pressure and the resulting acid chloride was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07956052B2 |
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| Source dataset | uspto-grants-2011_06 |
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| ORD ID | ord-9bea5181dc8d48dfb9d8c0097fbd1346 |
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| Source note | uspto-grants-2011_06 |
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