Methylamine → HCID 86585161, compound

Participants

Reaction Steps

Commercially available ethyl 4-chloro-2-methylthiopyrimidine-5-carboxylate (9.70 g) was reacted with methylamine in a similar manner to the second stage in Step 1 of Reference Example 1. The reaction mixture was purified by silica gel chromatography (chloroform/methanol) to give ethyl 4-methylamino-2-methylthiopyrimidine-5-carboxylate (8.37 g, yield 88%). Subsequently, the resulting compound was treated in a similar manner to Steps 1 and 2 of Reference Example 1 to give 4-methylamino-2-methylthiopyrimidine-5-carbohydrazide (5.78 g, yield 74%).

Provenance & Evidence