HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2421013Generated: November 3, 2026
N-bromobutanimide → Ethyl 5-bromo-6-hydroxy-2-(trifluoromethyl)nicotinate
https://huagongshe.com/reaction/2421013
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Ethyl 6-oxo-2-(trifluoromethyl)-1,6-dihydropyridine-3-carboxylate | HCID 18374262 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | Ethyl 5-bromo-6-hydroxy-2-(trifluoromethyl)nicotinate | HCID 57900861 | 74.9% |
Reaction Steps
To a solution of ethyl 6-oxo-2-(trifluoromethyl)-1,6-dihydropyridine-3-carboxylate (Organic Process Research and Development 1997, 1, 370-378; 0.10 g) in carbon tetrachloride was added N-bromosuccinimide (0.083 g). The mixture was heated at 80° C. for 24 h. Evaporation and the purification by flash column chromatography gave the subtitle compound as a colourless solid (0.10 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07956070B2 |
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| Source dataset | uspto-grants-2011_06 |
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| ORD ID | ord-5f8ac24c12964989851de8bdfe2090f9 |
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| Source note | uspto-grants-2011_06 |
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