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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2421014Generated: November 1, 2026

Ethyl 5-bromo-6-hydroxy-2-(trifluoromethyl)nicotinate → 5-Bromo-6-oxo-2-(trifluoromethyl)-1,6-dihydropyridine-3-carboxylic acid

https://huagongshe.com/reaction/2421014

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 5-bromo-6-hydroxy-2-(trifluoromethyl)nicotinateHCID 57900861—
SolventHydrochloric AcidHCID 313—
Product5-Bromo-6-oxo-2-(trifluoromethyl)-1,6-dihydropyridine-3-carboxylic acidHCID 6721500692.2%

Reaction Steps

Ethyl 5-bromo-6-oxo-2-(trifluoromethyl)-1,6-dihydropyridine-3-carboxylate (0.25 g) was suspended in 30% aqueous hydrochloric acid and heated at reflux for 4 days. Cooling and filtration gave the subtitle compound (0.210 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07956070B2
Source datasetuspto-grants-2011_06
ORD IDord-feadf6a1f8eb47b48386ad96c88d6657
Source noteuspto-grants-2011_06