2-Oxo-4-(trifluoromethyl)-2,3-dihydro-1,3-thiazole-5-carboxylic acid → HCID 11156984, compound

HRID 2421018Notes

Reaction equation

HRID 2421018 reaction equation
[Cl:1][C:2]1[C:20]([CH3:21])=[C:19]([Cl:22])[CH:18]=[CH:17][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([CH2:11][C@H:12]([OH:16])[CH2:13][NH:14][CH3:15])[CH2:7][CH2:6]1.[O:23]=[C:24]1[NH:28][C:27]([C:29]([F:32])([F:31])[F:30])=[C:26]([C:33]([OH:35])=O)[S:25]1>>[Cl:1][C:2]1[C:20]([CH3:21])=[C:19]([Cl:22])[CH:18]=[CH:17][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([CH2:11][C@H:12]([OH:16])[CH2:13][N:14]([CH3:15])[C:33]([C:26]2[S:25][C:24](=[O:23])[NH:28][C:27]=2[C:29]([F:30])([F:31])[F:32])=[O:35])[CH2:7][CH2:6]1

Participants

3

Reactant 2

HCID 198845762-Oxo-4-(trifluoromethyl)-2,3-dihydro-1,3-thiazole-5-carboxylic acidHCID 58830513HCID 58830513, compound

Product 1

HCID 11156984HCID 11156984, compoundYield 37.3%

Procedure

Prepared as Example 1 using (2R)-1-[4-(2,4-dichloro-3-methylphenoxy)piperidin-1-yl]-3-(methylamino)propan-2-ol (0.156 g) and 2-oxo-4-(trifluoromethyl)-2,3-dihydro-1,3-thiazole-5-carboxylic acid (0.096 g) to yield the title compound as a colourless solid (0.091 g).

Sources & evidence

ORD record
ord-daa18b9b30ba40749a43a7a29bc4edea
Source dataset
uspto-grants-2011_06
Patent number
US07956070B2

Reaction notes

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