(2R)-1-amino-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl)propan-2-ol → HCID 11432995, compound

HRID 2421019Notes

Reaction equation

HRID 2421019 reaction equation
[NH2:1][CH2:2][C@@H:3]([OH:20])[CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([Cl:19])[CH:13]=2)[CH2:7][CH2:6]1.[O:21]=[C:22]1[NH:26][C:25]([C:27]([F:33])([F:32])[C:28]([F:31])([F:30])[F:29])=[C:24]([C:34](O)=[O:35])[S:23]1>>[Cl:19][C:14]1[CH:13]=[C:12]([CH:17]=[CH:16][C:15]=1[Cl:18])[O:11][CH:8]1[CH2:9][CH2:10][N:5]([CH2:4][C@H:3]([OH:20])[CH2:2][NH:1][C:34]([C:24]2[S:23][C:22](=[O:21])[NH:26][C:25]=2[C:27]([F:33])([F:32])[C:28]([F:31])([F:30])[F:29])=[O:35])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 11151315(2R)-1-amino-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl)propan-2-olHCID 86611244HCID 86611244, compound

Product 1

HCID 11432995HCID 11432995, compoundYield 26.5%

Procedure

Prepared as Example 1 using (2R)-1-amino-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propan-2-ol (0.158 g) and 2-oxo-4-(pentafluoroethyl)-2,3-dihydro-1,3-thiazole-5-carboxylic acid (0.130 g) to yield the title compound as a colourless solid (0.074 g).

Sources & evidence

ORD record
ord-5ca4c97b3a624356bb5475db900b903a
Source dataset
uspto-grants-2011_06
Patent number
US07956070B2

Reaction notes

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