HCID 59296026, compound → HCID 178433728, compound

HRID 2421020Notes

Reaction equation

HRID 2421020 reaction equation
[NH2:1][CH2:2][C@@H:3]([OH:21])[CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([CH3:19])[C:13]=2[Cl:20])[CH2:7][CH2:6]1.[CH3:22][C:23]1[NH:27][N:26]=[N:25][C:24]=1[C:28](O)=[O:29]>>[Cl:20][C:13]1[C:14]([CH3:19])=[C:15]([Cl:18])[CH:16]=[CH:17][C:12]=1[O:11][CH:8]1[CH2:9][CH2:10][N:5]([CH2:4][C@H:3]([OH:21])[CH2:2][NH:1][C:28]([C:24]2[N:25]=[N:26][NH:27][C:23]=2[CH3:22])=[O:29])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 59296026HCID 59296026, compoundHCID 178433730HCID 178433730, compound

Product 1

HCID 178433728HCID 178433728, compound

Procedure

Prepared as Example 1 using (2R)-1-amino-3-[4-(2,4-dichloro-3-methylphenoxy)piperidin-1-yl]propan-2-ol (0.158 g) and 5-methyl-1H-1,2,3-triazole-4-carboxylic acid to yield the title compound as a colourless solid (0.037 g).

Sources & evidence

ORD record
ord-98b5aa3079fc45cfb901338715cf53e1
Source dataset
uspto-grants-2011_06
Patent number
US07956070B2

Reaction notes

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