HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2421030Generated: October 25, 2026
N-bromobutanimide → Ethyl 6-oxo-2-(pentafluoroethyl)-1,6-dihydropyridine-3-carboxylate
https://huagongshe.com/reaction/2421030
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Ethyl 6-oxo-2-(pentafluoroethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate | HCID 86611248 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | Ethyl 6-oxo-2-(pentafluoroethyl)-1,6-dihydropyridine-3-carboxylate | HCID 86611249 | 43.8% |
Reaction Steps
A suspension of ethyl 6-oxo-2-(pentafluoroethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate (0.690 g) and N-bromosuccinimide (0.427 g) in carbon tetrachloride (5 mL) was heated at 80° C. for 20 h. The reaction mixture was concentrated in vacuo and subjected to flash column chromatography (eluent 1:3 ethyl acetate/isohexane) to yield a colourless solid (0.30 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07956070B2 |
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| Source dataset | uspto-grants-2011_06 |
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| ORD ID | ord-885a408ad58b46549dc94731e4f37375 |
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| Source note | uspto-grants-2011_06 |
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