3-(2-Tert-butoxy-2-oxoethoxy)-4-chlorobenzoic acid → Tert-butyl{2-chloro-5-[({(2r)-3-[4-(3,4-dichloro-2-methylphenoxy)piperidin-1-yl]-2-hydroxypropyl}amino)carbonyl]phenoxy}acetate

HRID 2421044Notes

Reaction equation

HRID 2421044 reaction equation
[C:1]([O:5][C:6](=[O:19])[CH2:7][O:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][C:17]=1[Cl:18])[C:12]([OH:14])=O)([CH3:4])([CH3:3])[CH3:2].[NH2:20][CH2:21][C@@H:22]([OH:40])[CH2:23][N:24]1[CH2:29][CH2:28][CH:27]([O:30][C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[C:33]([Cl:38])[C:32]=2[CH3:39])[CH2:26][CH2:25]1>>[C:1]([O:5][C:6](=[O:19])[CH2:7][O:8][C:9]1[CH:10]=[C:11]([C:12]([NH:20][CH2:21][C@@H:22]([OH:40])[CH2:23][N:24]2[CH2:29][CH2:28][CH:27]([O:30][C:31]3[CH:36]=[CH:35][C:34]([Cl:37])=[C:33]([Cl:38])[C:32]=3[CH3:39])[CH2:26][CH2:25]2)=[O:14])[CH:15]=[CH:16][C:17]=1[Cl:18])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 672147983-(2-Tert-butoxy-2-oxoethoxy)-4-chlorobenzoic acidHCID 67215078(2R)-1-amino-3-[4-(3,4-dichloro-2-methylphenoxy)piperidin-1-yl]propan-2-ol

Product 1

HCID 131728945Tert-butyl{2-chloro-5-[({(2r)-3-[4-(3,4-dichloro-2-methylphenoxy)piperidin-1-yl]-2-hydroxypropyl}amino)carbonyl]phenoxy}acetate

Procedure

Prepared as for Example 15, Step 2 using 3-(2-tert-butoxy-2-oxoethoxy)-4-chlorobenzoic acid and (2R)-1-amino-3-[4-(3,4-dichloro-2-methylphenoxy)piperidin-1-yl]propan-2-ol to yield the subtitle compound as a colourless oil (0.14 g).

Sources & evidence

ORD record
ord-7acb56e6b7fa4c00b10457308e0b175b
Source dataset
uspto-grants-2011_06
Patent number
US07956070B2

Reaction notes

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