HuagongsheHuagongshe Chemistry Print Report · For research reference only
[3-(Methoxycarbonyl)phenoxy]acetic acid → Methyl 3-[2-({(2r)-3-[4-(3,4-dichloro-2-methylphenoxy)piperidin-1-yl]-2-hydroxypropyl}amino)-2-oxoethoxy]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [3-(Methoxycarbonyl)phenoxy]acetic acid | HCID 13816150 | — |
| Reactant | (2R)-1-amino-3-[4-(3,4-dichloro-2-methylphenoxy)piperidin-1-yl]propan-2-ol | HCID 67215078 | — |
| Product | Methyl 3-[2-({(2r)-3-[4-(3,4-dichloro-2-methylphenoxy)piperidin-1-yl]-2-hydroxypropyl}amino)-2-oxoethoxy]benzoate | HCID 67214558 | — |
Reaction Steps
Prepared as for Example 15, Step 2 using [3-(methoxycarbonyl)phenoxy]acetic acid [Asian Journal of Chemistry 1992, 4(4), 920-3] and (2R)-1-amino-3-[4-(3,4-dichloro-2-methylphenoxy)piperidin-1-yl]propan-2-ol to yield the subtitle compound as a pale yellow oil (0.11 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07956070B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-83a299cfda914fdd9fd14630b85773e8 |
| Source note | uspto-grants-2011_06 |