Sodium borohydride → HCID 86653007, compound

Participants

Reaction Steps

N-[2-({1-[1-(6-Chloropyridin-2-yl)cyclobutyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethyl]propane-1-sulfonamide (36 mg, 0.78 mmol) was dissolved in methanol (1 ml). Sodiumborohydride (12 mg, 0.31 mmol) was added and stirring was continued at room temperature over night. The solvent was evaporated in vacuo and the residue partitioned between dichloromethane and 1N aqueous sodium hydroxide solution. The layers were separated and the organic layer was dried (MgSO4) and concentrated in vacuo. The crude product was used for the next step without further purification. Yield: 9 mg.

Provenance & Evidence