1,1'-Carbonyldiimidazole → HCID 67215086, compound

Participants

Reaction Steps

To a solution of compound {4-(2-aminocyclohexylamino)-piperidine-1-carboxylic acid benzyl ester)} (1.48 g, 4.47 mmoles) in acetonitrile (50 mL), 1,1′-carbonyldiimidazole (0.86 g, 5.36 mmole) was added and the reaction mixture was stirred at room temperature for 18 h. Reaction mixture was concentrated under reduced pressure, dissolved again in dichloromethane (60 mL) washed with water (2×100 mL) and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to give the title compound as a solid (1.45 g, 90%). MS: (M+1): 358.13

Provenance & Evidence