2-Nitrobenzoic acid → HCID 67214857, compound

HRID 2421101Notes

Reaction equation

HRID 2421101 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]([NH:15][NH2:16])=[O:14].[N+:17]([C:20]1[CH:28]=[CH:27][CH:26]=[CH:25][C:21]=1[C:22](O)=O)([O-:19])=[O:18]>>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]1[O:14][C:22]([C:21]2[CH:25]=[CH:26][CH:27]=[CH:28][C:20]=2[N+:17]([O-:19])=[O:18])=[N:16][N:15]=1

Participants

3

Reactant 2

HCID 110872-Nitrobenzoic acidHCID 7279245-Methyl-3-phenyl-4-isoxazolecarbohydrazide

Product 1

HCID 67214857HCID 67214857, compoundYield 79%

Procedure

As described for example 2, 5-methyl-3-phenyl-isoxazole-4-carboxylic acid hydrazide (2.00 g, 9.12 mmol) was converted using 2-nitro-benzoic acid instead of o-toluic acid to the title compound (2.52 g, 79%) which was obtained as a light-brown solid. MS: m/e=349.1 [M+H]+.

Sources & evidence

ORD record
ord-aca337d2ce754c00af05398fa1016fb4
Source dataset
uspto-grants-2011_06
Patent number
US07956074B2

Reaction notes

Loading…