Piperidin-4-ol → 1-{3-Methoxy-4-[5-(5-methyl-3-phenyl-isoxazol-4-yl)-[1,3,4]oxadiazol-2-yl]-phenyl}-piperidin-4-ol

Participants

Reaction Steps

As described for example 26, 2-(4-fluoro-2-methoxy-phenyl)-5-(5-methyl-3-phenyl-isoxazol-4-yl)-[1,3,4]oxadiazole (200 mg, 0.57 mmol) was converted using 4-hydroxy-piperidine instead of thiomorpholine to the title compound (SiO2, dichloromethane:methanol=100:0 to 90:10, 197 mg, 79%) which was obtained as an off-white solid. MS: m/e=433.3 [M+H]+.

Provenance & Evidence