Dimethylamine, hydrochloride → HCID 16722949, compound

Participants

Reaction Steps

As described for example 26, 2-(4-fluoro-2-methoxy-phenyl)-5-(5-methyl-3-phenyl-isoxazol-4-yl)-[1,3,4]oxadiazole (200 mg, 0.57 mmol) was converted using dimethylamine hydrochloride (232 mg, 2.85 mmol) and N,N-diisopropylethylamine (294 mg, 2.28 mmol) instead of thiomorpholine to the title compound (SiO2, heptane:ethyl acetate:dichloromethane 70:10:20 to 40:40:20, 8 mg, 4%) which was obtained as a light brown solid. MS: m/e=377.3 [M+H]+.

Provenance & Evidence