HCID 58951536, compound → HCID 58951515, compound

Participants

Reaction Steps

2.4 g of tert-butyl 2-((1R,3S)-3-hydroxycyclohexylmethoxy)-2-methylpent-4-enoate are issolved in 15 ml of ethyl acetate and, under an argon atmosphere in an autoclave, a patula tip of Pd/C (10%) is added. The autoclave is then flushed with H2, and the solution is stirred with an H2 pressure of 3 bar at RT overnight. The catalyst is then iltered off through Celite, and the filtrate is concentrated, resulting in 2.3 g of tert-butyl 2-((1R,3S)-3-hydroxycyclohexylmethoxy)-2-methylpentanoate as a mixture of two iastereomers as pale yellow oil.

Provenance & Evidence