Potassium Carbonate → HCID 59627919, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-methyl-4-[(phenylmethyl)oxy]-1H-indole {WO9204321} (440 mg, 1.86 mmol) in N-methyl-2-pyrrolidinone (4 mL) was added 4-bromo-2-fluorophenol (0.205 mL, 1.87 mmol), copper iodide (70 mg, 0.37 mmol) and potassium carbonate (641 mg, 4.64 mmol). The reaction mixture was heated in a Biotage Initiator™ Microwave Synthesizer at 190° C. for 6 hours. The mixture was filtered through a pad of Celite which was subsequently washed with ethyl acetate. The ethyl acetate solution was washed with water, dried over magnesium sulfate, filtered and then concentrated in vacuo. The product was purified by MDAP to yield the title compound (D3) (30 mg).

Provenance & Evidence