反应详情

温度

90 °C

To a solution of 6-bromo-4-(methyloxy)-1H-indole (900 mg, 3.98 mmol) in 1,2-dimethoxyethane (20 mL) was added tributylvinyltin (1.74 mL, 5.96 mmol). The reaction mixture was degassed with argon and then treated with dichlorobis(tri-o-tolylphosphine)palladium (153 mg, 0.19 mmol). The mixture was heated at 90° C. for 65 hours. The mixture was filtered through a pad of celite, washed with ethyl acetate and then the filtrate concentrated in vacuo. The product was purified by silica gel chromatography eluting with 2-50% ethyl acetate in hexane to yield the title compound (D8), (781 mg).

1. customThe reaction mixture was degassed with argon
2. filtrationThe mixture was filtered through a pad of celite
3. washwashed with ethyl acetate
4. concentrationthe filtrate concentrated in vacuo
5. customThe product was purified by silica gel chromatography
6. washeluting with 2-50% ethyl acetate in hexane