HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Ethenyl-1-[3-fluoro-4-(methyloxy)phenyl]-4-(methyloxy)-1H-indole → 6-Ethyl-1-[3-fluoro-4-(methyloxy)phenyl]-4-(methyloxy)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Ethenyl-1-[3-fluoro-4-(methyloxy)phenyl]-4-(methyloxy)-1H-indole | HCID 67136453 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 6-Ethyl-1-[3-fluoro-4-(methyloxy)phenyl]-4-(methyloxy)-1H-indole | HCID 59627937 | 89.7% |
Reaction Steps
A solution of 6-ethenyl-1-[3-fluoro-4-(methyloxy)phenyl]-4-(methyloxy)-1H-indole (D9) (200 mg, 0.67 mmol) in ethanol (7 mL) and ethyl acetate (7 mL) was hydrogenated in an H-cube over a 10% palladium on charcoal catalyst. The resulting solution was concentrated and the product purified by silica gel chromatography eluting with 5-70% dichloromethane in hexane to yield the title compound (D10), (180 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07956083B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-2712d8473fd74af9a496334741d3cacb |
| Source note | uspto-grants-2011_06 |