反应详情

温度

85 °C

A mixture of 4-bromo-6-fluoro-1-{4-[(phenylmethyl)oxy]phenyl}-1H-indole (D19) (200 mg, 0.505 mmol) and potassium hydroxide (113 mg, 2.02 mmol) in 1,4-dioxan (3 mL)/water (3 mL) was treated with Pd2dba3 (9 mg, 0.02 mmol) and phosphine ligand, bis(1,1-dimethylethyl)[2′,4′,6′-tris(1-methylethyl)-2-biphenylyl]phosphane (11 mg, 0.05 mmol) and the mixture was heated to 85° C. for 1.5 hours. After cooling, the mixture was diluted with dichloromethane and water and the product was extracted into dichloromethane. The combined organic layers were dried (MgSO4) and evaporated. Chromatography on silica gel (elution with 0-50% ethyl acetate in hexane) gave the title compound (D20), (75 mg).

1. temperatureAfter cooling
2. extractionthe product was extracted into dichloromethane
3. dry with materialThe combined organic layers were dried (MgSO4)
4. customevaporated