反应详情

A mixture of 6-fluoro-1-{4-[(phenylmethyl)oxy]phenyl}-1H-indol-4-ol (D20) (75 mg) and palladium on charcoal (75 mg) in ethanol (3 mL) was stirred under hydrogen at room temperature for 3 hours. The mixture was filtered and the filtrate was evaporated and chromatographed on silica gel (0-50% ethyl acetate in hexane). The product containing fractions were concentrated and then re-evaporated from ether (3×) to give the title compound (E10) as a white solid, (15 mg).

1. filtrationThe mixture was filtered
2. customthe filtrate was evaporated
3. customchromatographed on silica gel (0-50% ethyl acetate in hexane)
4. additionThe product containing fractions
5. concentrationwere concentrated
6. customre-evaporated from ether (3×)