2-Bromo-1-[3,5-di(tert-butyl)-4-hydroxyphenyl]ethan-1-one → HCID 67214011, compound

HRID 2421291Notes

Reaction equation

HRID 2421291 reaction equation
[C:1]([C:5]([O:7][CH2:8][C:9]([NH2:11])=[S:10])=[O:6])([CH3:4])([CH3:3])[CH3:2].Br[CH2:13][C:14]([C:16]1[CH:29]=[CH:28][C:27]2[S:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[N:19](C(=O)CCl)[C:18]=2[CH:17]=1)=O.BrCC(C1C=C(C(C)(C)C)C(O)=C(C(C)(C)C)C=1)=O>>[C:5]([O:7][CH2:8][C:9]1[S:10][CH:13]=[C:14]([C:16]2[CH:29]=[CH:28][C:27]3[S:26][C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[NH:19][C:18]=3[CH:17]=2)[N:11]=1)(=[O:6])[C:1]([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 3

HCID 6161612-Bromo-1-[3,5-di(tert-butyl)-4-hydroxyphenyl]ethan-1-oneHCID 27821132-Amino-2-thioxoethyl 2,2-dimethylpropanoateHCID 86108827HCID 86108827, compound

Product 1

HCID 67214011HCID 67214011, compoundYield 63.2%

Procedure

This compound is prepared according to a protocol identical to that described for Stage 350.3 of Example 350, respectively using 2-(tert-butylcarbonyloxy)thioacetamide and 2-bromo-1-[10-(chloroacetyl)-10H-phenothiazin-2-yl]ethanone instead of intermediate 1.2 and bromo-1-(3,5-ditert-butyl-4-hydroxyphenyl)ethanone. The expected compound is obtained in the form of a greenish solid with a yield of 63.2%. Melting point: 120.0-122.0° C.

Workup

  1. customThis compound is prepared

Sources & evidence

ORD record
ord-feca8e0f4894409e9a0cb0187e2ccfa5
Source dataset
uspto-grants-2011_06
Patent number
US07956075B2

Reaction notes

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