HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 242133Generated: October 26, 2026
Thionyl Chloride → 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl chloride
https://huagongshe.com/reaction/242133
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropanecarboxylic acid | HCID 44206103 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl chloride | HCID 57516850 | — |
Reaction Steps
1-(2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarboxylic acid (1.2 eq) is slurried in toluene (2.5 vol) and the mixture heated to 60° C. SOCl2 (1.4 eq) is added via addition funnel. The toluene and SOCl2 are distilled from the reaction mixture after 30 minutes. Additional toluene (2.5 vol) is added and distilled again.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08653103B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-2ba021db2ee34f3cbbd0bece7bdffa75 |
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| Source note | uspto-grants-2014_02 |
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