p-Toluenesulfonate → p-Toluenesulfonic acid monohydrate

Participants

Reaction Conditions

Reaction Steps

An aliquot (1.5 g, 2.2 mmol) of the tosylate anhydrous form 1 salt form of the compound of Formula I prepared above was combined with 9.0 mL of water in a sealed container for 3 days producing a scum-like material. The scum-like material was collected, broken apart, and combined with an additional 15 mL of water, producing a slurry. The slurry was shaken at 25° C. and 350 RPM for six days producing a wet cake. An additional 45 mL of water was added to the wet cake, producing a slurry, which was shaken at 25° C. and 350 RPM for five days. After the shaking period had ended the resulting solids were collected by vacuum filtration and dried under vacuum at room temperature overnight, providing the tosylate hydrate Form I salt form of the compound of Formula I.

Provenance & Evidence