p-Toluenesulfonate → p-Toluenesulfonic acid monohydrate

Participants

Reaction Conditions

Reaction Steps

An aliquot (1.5 g, 2.2 mmol) of the tosylate anhydrous form 1 salt form of the compound of Formula I prepared above was dissolved in 4.5 mL of methanol. The solution was concentrated to dryness after 3 days by vacuum distillation. The solids were slurried in 4.5 mL of 2-propanol which was shaken at 25° C. and 350 RPM for six days yielding precipitate. The solids were collected by vacuum filtration and dried under vacuum at room temperature over a 12 hour period. The resulting crystalline tosylate hydrate form 2 salt form of the compound of Formula I was analyzed by X-ray crystallography (FIG. 21), DSC (FIG. 22), and TGA (FIG. 23) in accordance with the procedures described above.

Provenance & Evidence