HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-(Chloromethyl)-N-(4-fluorophenyl)-6-methylpyrimidine-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | {2-[(4-Fluorophenyl)amino]-6-methylpyrimidin-4-yl}methanol | HCID 59278633 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(Chloromethyl)-N-(4-fluorophenyl)-6-methylpyrimidine-2-amine | HCID 59278648 | — |
Reaction Steps
At 0° C., 225 mg (0.96 mmol) of the compound from example 6A and 137 mg (1.16 mmol) of thionyl chloride are initially charged in 10 ml of dichloromethane and, after warming to RT, stirred at this temperature for 24 h. The solvent is removed on a rotary evaporator and the product that remains is directly reacted further.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08653109B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-4600fafe061d4f6399db50d26ec7e638 |
| Source note | uspto-grants-2014_02 |