Thionyl Chloride → HCID 59160958, compound

HRID 242151Notes

Reaction equation

HRID 242151 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([NH:7][C:8]2[N:13]=[C:12]([CH2:14]O)[CH:11]=[CH:10][CH:9]=2)=[CH:3][CH:2]=1.S(Cl)([Cl:18])=O>ClCCl>[Cl:18][CH2:14][C:12]1[N:13]=[C:8]([NH:7][C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)[CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 59161030HCID 59161030, compound

Product 1

HCID 59160958HCID 59160958, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

At 0° C., 50 mg (0.22 mmol) of the compound from example 8A and 53 mg (0.44 mmol) of thionyl chloride are initially charged in 1.5 ml of dichloromethane and, after warming to RT, stirred at this temperature for 12 h. The solvent is removed on a rotary evaporator and the product that remains is directly reacted further.

Workup

  1. customThe solvent is removed on a rotary evaporator
  2. customthe product that remains is directly reacted further

Sources & evidence

ORD record
ord-4d37ea42850245a9af2506c1f95be2b2
Source dataset
uspto-grants-2014_02
Patent number
US08653109B2

Reaction notes

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