HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3-Chloro-6-(chloromethyl)pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (6-Chloropyridazin-3-yl)methanol | HCID 20557609 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Chloro-6-(chloromethyl)pyridazine | HCID 22498639 | — |
Reaction Steps
At 0° C., 200 mg (1.38 mmol) of the compound from example 10A and 198 mg (1.66 mmol) of thionyl chloride are initially charged in 1.5 ml of dichloromethane and, after warming to RT, stirred at this temperature for 24 h. The solvent is removed on a rotary evaporator and the product that remains is directly reacted further.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08653109B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-8b35af9988984d4588c8e0fda87ab1d5 |
| Source note | uspto-grants-2014_02 |