Water → Diisopropylcarbodiimide

Participants

Reaction Steps

A solution of Fmoc-4-aminophenylacetic acid (0.098M), HOBt.H2O (0.12M) and DIC (0.2M) in 20% DMF/DCM was prepared. To this solution was added the Fmoc-deprotected Lanterns. The mixture was then gently agitated at room temperature for 21 h. At the completion of the reaction, the coupling solution was removed and the Lanterns washed with DMF (3×10 min), 50% DMF/DCM (3×10 min) and DCM (3×10 min). The Lanterns were air-dried overnight.

Provenance & Evidence