Water → Diisopropylcarbodiimide

Participants

Reaction Steps

A solution of Fmoc-4-aminophenylacetic acid (0.098M), HOBt.H2O (0.12M) and DIC (0.2M) in 20% DMF/DCM was prepared. To this solution was added the Fmoc-deprotected Lanterns. The mixture was then gently agitated at room temperature for 21 h. At the completion of the reaction, the Lanterns were drained and washed with DMF (3×10 min), 50% DMF/DCM (3×10 min) and DCM (3×10 min), then air-dried overnight.

Provenance & Evidence