Phenylboronic Acid → N-n-propyl-3-phenylbenzamide

HRID 2421586Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2421586
[CH2:1]([NH:4][C:5](=[O:13])[C:6]1[CH:11]=[CH:10][CH:9]=[C:8](Br)[CH:7]=1)[CH2:2][CH3:3].[C:14]1(B(O)O)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:1]([NH:4][C:5](=[O:13])[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:7]=1)[CH2:2][CH3:3]

Komponenten

3

Edukt 2

HCID 66827Phenylboronic AcidHCID 31186553-bromo-N-propylbenzamide

Produkt 1

HCID 4730717N-n-propyl-3-phenylbenzamideAusbeute 96 %

Versuchsvorschrift

Using Preparation Method 2, N-n-propyl-3-bromobenzamide from Example 1A was reacted with phenyl boronic acid. The resulting reaction mixture was purified using SiO2 with CH2Cl2 (100%) to CH2Cl2/MeOH 90:10 to give N-n-propyl-3-phenylbenzamide as a white solid (96%). NMR 1H (ppm, CDCl3): 7.97 (t, J4=1.53 Hz, 1H), 7.69 (dd, J3=7.91 Hz, J4=1.84 Hz, 2H), 7.61-7.58 (m, 2H), 7.51-7.24 (m, 4H), 6.17 (br. s., 1H), 3.47-3.40 (m, 2H), 1.65 (sext., J3=7.32 Hz, 2H), 0.98 (t, J3=7.38 Hz, 3H).

Aufarbeitung

  1. customThe resulting reaction mixture
  2. customwas purified

Quellen und Nachweise

ORD-Eintrag
ord-d1c3e3b57892430283c309dd165ffa64
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07956216B2

Notizen zur Reaktion

Wird geladen…