反应详情

Using Preparation Method 2, N-n-propyl-3-bromobenzamide from Example 1A was reacted with 1-naphthylboronic acid. The resulting reaction mixture was purified using SiO2 with CH2Cl2/Petroleum ether 80:20 to CH2Cl2/AcOH 80:20 to give a thick yellow oil (75%). NMR 1H (ppm, CDCl3): 7.92-7.78 (m, 5H), 7.67-7.40 (m, 6H), 6.16 (br. s., 1H), 3.50-3.36 (m, 2H), 1.64 (sext., J3=7.33 Hz, 2H), 0.97 (t, J3=7.38 Hz, 3H).

1. customThe resulting reaction mixture
2. customwas purified