反应详情

Using Preparation Method 2, N-n-propyl-3-bromobenzamide from Example 1A was reacted with 2-naphthylboronic acid. The resulting reaction mixture was purified using SiO2 with CH2Cl2/Petroleum ether 80:20 to CH2Cl2/AcOH 80:20 to give a white solid (57%). NMR 1H (ppm, CDCl3): 8.12 (t, J4=1.65 Hz, 1H), 8.06 (s, 1H), 7.91 (t, J3=8.37 Hz, 2H), 7.83 (d, J3=7.81 Hz, 2H), 7.73 (td, J3=8.51 Hz, J4=1.79 Hz, 2H), 7.55-7.46 (m, 3H), 6.18 (br. s., 1H), 3.49-3.43 (m, 2H), 1.67 (sext., J3=7.31 Hz, 2H), 1.00 (t, J3=7.37 Hz, 3H).

1. customThe resulting reaction mixture
2. customwas purified