(1,1'-Biphenyl)-4-carboxylic acid → HCID 67214377, compound

HRID 2421606Notes

Reaction equation

HRID 2421606 reaction equation
[C:1]1([C:7]2[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:16]1[CH2:18][CH:17]1[CH2:19][CH2:20][NH2:21]>>[CH2:16]1[CH2:18][CH:17]1[CH2:19][CH2:20][NH:21][C:11](=[O:13])[C:10]1[CH:9]=[CH:8][C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 66724(1,1'-Biphenyl)-4-carboxylic acidHCID 10240761Cyclopropaneethanamine

Product 1

HCID 67214377HCID 67214377, compound

Procedure

Using Preparation Method 1, 4-phenylbenzoic acid was reacted with (2-cyclopropyl)ethylamine. The resulting reaction mixture was purified using SiO2 with CH2Cl2 100%. A white crystalline solid was obtained (29%). NMR 1H (ppm, CDCl3): 7.82 (d, J3=8.2 Hz, 2H), 7.64 (d, J3=8.4 Hz, 2H), 7.60 (d, J3=7.5 Hz, 2H), 7.47-7.34 (m, 3H), 6.26 (br. s., 1H), 3.60-3.53 (m, 2H), 1.54 (quart., J3=6.8 Hz, 2H), 0.76-0.71 (m, 1H), 0.51-0.48 (m, 2H), 0.13-0.11 (m, 2H).

Workup

  1. customThe resulting reaction mixture
  2. customwas purified
  3. customA white crystalline solid was obtained (29%)

Sources & evidence

ORD record
ord-448416f202f24d65bee30bcdc52047d5
Source dataset
uspto-grants-2011_06
Patent number
US07956216B2

Reaction notes

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