Ethanol → HCID 67214482, compound

Participants

Reaction Steps

Using Preparation Method 2, 68C (247 mg, 0.82 mmol) was reacted with phenyl boronic acid (109 mg, 0.9 mmol) in the presence of 5 mol % Pd(PPh3)4, 0.82 mL of 2N Na2CO3, 0.43 mL of Ethanol and 1.8 mL of toluene. The resulting reaction mixture was purified using SiO2 with CH2Cl2/AcOEt 98:2 to 90:10 to give a greenish oil (284 g, quant.). NMR 1H (ppm, CDCl3): 8.37 (t, J4=1.64 Hz, 1H), 8.27 (d. t., J3=6.03 Hz, J4=1.75 Hz, 1H), 7.63 (d, J3=6.97 Hz, 1H), 7.49-7.36 (m, 5H), 6.27 (br. s., 1H), 3.49-3.42 (m, 2H), 1.64 (sext., J3=7.25 Hz, 2H), 1.00 (t., J3=7.37 Hz, 3H).

Provenance & Evidence