Propylamine → HCID 67215101, compound

Participants

Reaction Steps

Using preparation method 1, 74B (224 mg, 1 mmol) was reacted with n-propylamine (90 μL, 65 mg, 1.1 mmol). The product was purified by flash chromatography on SiO2 using CH2Cl2/hexanes 40:60 to CH2Cl2/hexanes 60:40. White crystals were obtained (154 mg, 58%). NMR 1H (ppm, CDCl3): 7.92 (s, 1H), 7.60 (t, J3=7.7 Hz, 2H), 7.51 (d, J3=7.8 Hz, 2H), 7.40 (t, J3=7.6 Hz, 1H), 7.36 (t, J3=7.5 Hz, 2H), 7.29-7.26 (m, 1H), 7.18 (d, J3=16.4 Hz, 1H), 7.10 (d, J3=16.3 Hz, 1H), 6.12 (br. s, 1H), 3.47-3.40 (m, 2H), 1.65 (sext., J3=7.2 Hz, 2H), 1.00 (t, J3=7.4 Hz, 3H).

Provenance & Evidence