Phenylacetic Acid → HCID 11106514, compound

Participants

Reaction Steps

EDAC.HCl (959 mg, 5 mmol) was added to a mixture of phenylacetic acid (821 mg, 5 mmol), propylamine (411 μL, 5 mmol) and HOBT (676 mg, 5 mmol) in 5 mL of CH3CN. The reaction was stirred for 72 hours. After this time, the mixture was diluted with AcOEt. The organic layer was washed three times with HCl 2N, three times with NaOH 2N, dried over MgSO4 and concentrated. A with solid was obtained (698 mg, 68%). NMR 1H (ppm, CDCl3): 7.26-7.21 (m, 2H), 7.17-7.12 (m, 3H), 6.02 (br. s., 1H), 3.18-3.12 (m, 2H), 2.61 (t, J3=7.49 Hz, 2H), 2.15 (t, J3=7.14 Hz, 2H), 1.93 (q, J3=7.36 Hz, 2H), 1.47 (sex. J3=7.32 Hz, 2H), 0.88 (t, J3=7.37 Hz, 3H).

Provenance & Evidence