Benzyl Alcohol → HCID 1653334, compound

Participants

Reaction Conditions

Reaction Steps

In a 500 mL round bottom flask, fitted with a reflux, condenser, succinic anhydride (10.03 g, 1.2 eq.) and dimethylaminopyridine (10.2 g, 1 eq.) and benzyl alcohol (9.01 g, 1 eq.) in MTBE (250 mL) were combined. The reaction mixture was placed under inert atmosphere and stirred in an oil bath at 68° C. for 4 hours. The reaction was then quenched with a solution of 10% NaHCO3 and extracted with MTBE. The organic layer was washed with NaHCO3 and brine. The organic layer was collected, dried using MgSO4, and concentrated to give a white solid. The crude product was purified using column chromatography to give 14.1 g of white crystals.

Provenance & Evidence