Phosphorus tribromide → HCID 67120035, compound

Participants

Reaction Conditions

Reaction Steps

1-(4-Methoxyphenyl)-3-propyl-1H-pyrazol-5(4H)-one (495 mg, 2.13 mmol) was put in a microwave tube and closed, MeCN (2.1 mL) and PBr3 (6.4 mL, 68.2 mmol) were added via syringe and the reaction was stirred at 150° C. for 40 min in the microwave. The product poured onto ice and was extracted with EtOAc. The organic phase was separated from the water phase and evaporated. The crude product was purified on silica column (CH2Cl2/Et2O, 1:1) to give 5-bromo-1-(4-methoxyphenyl)-3-propyl-1H-pyrazole (287 mg, 46%).

Provenance & Evidence