Acetic Anhydride → HCID 11428649, compound

Participants

Reaction Steps

A solution of 1.5 g (4.6 mmoles) of 8-chloro-4-methyl-1-(3-methyl-4-nitrophenyl)-5H-2,3-benzodiazepine in 15 ml of acetic anhydride is stirred in an oil bath of 130 to 140° C. for 5 hours. The reaction mixture is poured onto about 200 g of crushed ice and the separated crystals are filtered off. The crude product is recrystallized from acetonitrile. Thus 0.78 g (46%) of the desired compound melting at a temperature of 192 to 194° C. is obtained.

Provenance & Evidence