Methanol → HCID 57896698, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 1-(piperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxylic acid (110 mg, 0.336 mmol) in DCE (5 mL) was added oxalyl chloride (293 μL, 3.36 mmol) and DMF (5 μL, 0.065 mmol). The reaction was heated to 50° C. and stirred at that temperature for 16 h. The reaction was concentrated in vacuo and used without further purification. The reaction yield was assumed to be 100% for calculation purposes only. LCMS (methanol adduct, i.e. the methyl ester; +ESI) m/z=342.1 [M+H]+.

Provenance & Evidence