Lithium hydroxide, monohydrate → HCID 57896690, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 1-tert-butyl 7-methyl 2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-1,7-dicarboxylate (1.25 g, 4.25 mmol) in methanol (20 mL) and water (5 mL) was added lithium hydroxide monohydrate (1.27 g, 30.3 mmol). The reaction was warmed to 40° C. and stirred at that temperature for 18 h. The reaction mixture was concentrated in vacuo to provide 1-(tert-butoxycarbonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxylic acid. The yield was assumed to be 100% for calculation purposes in subsequent reactions. LCMS (+ESI) m/z=281.1 [M+H]+.

Provenance & Evidence