Ammonia → HCID 57896851, compound

HRID 2421902Notes

Reaction equation

HRID 2421902 reaction equation
[F:1][C:2]([F:27])([F:26])[C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]2[CH2:17][CH2:16][O:15][C:14]3[N:18]=[CH:19][C:20]([C:22](OC)=[O:23])=[CH:21][C:13]2=3)(=[O:11])=[O:10])=[CH:5][CH:4]=1.[NH3:28]>CO>[F:1][C:2]([F:27])([F:26])[C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]2[CH2:17][CH2:16][O:15][C:14]3[N:18]=[CH:19][C:20]([C:22]([NH2:28])=[O:23])=[CH:21][C:13]2=3)(=[O:10])=[O:11])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 67243153HCID 67243153, compound

Product 1

HCID 57896851HCID 57896851, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of methyl 1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxylate (500 mg, 1.243 mmol) in 7 M NH3 in MeOH (10 mL) was heated to 60° C. and stirred at that temperature for 72 h. The solvent was removed under reduced pressure to provide 1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide (481 mg, 1.243 mmol, 100% yield) as a white solid. LCMS (+ESI) m/z=388.1 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-a1b6a79a498e4f75948b176a07394cb9
Source dataset
uspto-grants-2011_06
Patent number
US07960377B2

Reaction notes

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