Sodium Bicarbonate → HCID 57896719, compound

Participants

Reaction Steps

To a solution of N-(2-oxo-2-phenylethyl)-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide (40 mg, 0.079 mmol) in DMF (1 mL) was added ammonium acetate (61 mg, 0.791 mmol). The reaction was subjected to microwave irradiation (150° C., 30 min). The reaction mixture was treated with saturated aqueous NaHCO3 (1 mL) and extracted with EtOAc (2×1 mL). The combined organic layers were dried with sodium sulfate, filtered and evaporated. The residue was purified by flash column chromatography using a gradient elution of hexanes with 25-100% EtOAc Providing 7-(5-phenyl-1H-imidazol-2-yl)-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine (33 mg, 0.68 mmol, 86% yield) as a white/brown solid. LCMS (+ESI) m/z=487.0 [M+H]+; 1H-NMR (CDCl3) δ 8.69-8.67 (m, 2H), 7.82 (d, 2H), 7.75 (d, 2H), 7.72 (d, 2H), 7.42 (s, 1H), 7.36 (t, 2H) 7.26 (m, 2H) 3.95 (m, 2H), 3.84 (m, 2H).

Provenance & Evidence