Trifluoroacetic acid → 4-(2-Aminoethyl)benzonitrile

Participants

Reaction Steps

tert-Butyl [2-(4-cyanophenyl)ethyl]carbamate (1.14 g, 4.62 mmol) was dissolved in DCM (6 mL) and TFA (5 mL) was added. The mixture was concentrated and dissolved in EtOAc, and the organic phase was washed with saturated aqueous K2CO3. The organic layer was dried with Na2SO4, filtered and evaporated affording the title compound (0.50 g, 74.3%). 1H NMR (500 MHz, CDCl3): δ 1.21 (bs, 2H), 2.81 (t, 2H), 2.99 (t, 2H), 7.31 (d, 2H), 7.58 (d, 2H); 13C NMR (125 MHz, CDCl3): δ 40.38, 43.31, 110.33, 119.23, 129.86, 132.48, 145.93.

Provenance & Evidence